Publications
2025
Villaruz RH, Kuziek J, Sjonnesen K, Craddock L, Becker WJ, Harris AD*, Orr SL*. Chinook winds and migraine attack onset in children and adolescents: a prospective longitudinal clinical cohort study. Headache 2025 [accepted October 7, 2025]
Yuan H, Orr SL, Al-Karagholi M, Ashina M, Cohen F, Diener HC, Dodick D, Jensen R, Marmura MJ, Martinelli D, Matharu M, Petersen AS, Pozo-Rosich P, Sacco S, Simmonds L, Tassorelli C, Tepper S, Terwindt GM, Wang SJ, Yeh JT, Silberstein SD. International Headache Society evidence-based guidelines on the use of non-invasive neuromodulation devices for the acute and preventive treatment of migraine. Cephalalgia 2025; 45(10); DOI: https://doi.org/10.1177/03331024251388.
King J, Walters N, Rodrigues N, Bastami JA, Mehri N, Chan A, Spencer M, Ferrier E, Clark S, Orr SL, Rempel J, Hauenstein A, Roper J, Ralston J, Peters R. Electrical vestibular stimulation to improve static balance in older adults: a pilot randomized controlled trial. Journal of Neuroengineering 2025 [accepted September 9, 2025]
Espanioli A, Van Den Hoogen NJ, Kuziek J, Sjonnesen K, Noel MN, Orr SL. Exploring the relationship between pain catastrophizing and migraine in youth: a longitudinal clinical cohort study. Headache 2025; DOI: https://doi.org/10.1111/head.15039.
Beveridge JK, Noel M, McArthur BA, Madigan S, Orr SL, McDonald S, Tough S, Birnie KA. Identifying risk and protective factors in the transmission of chronic pain from mothers to children: a longitudinal cohort study. Pain 2025; DOI: 10.1097/j.pain.0000000000003698.
Marbil M, Galarneau JM, Yeates KO, Minich NM, Hershey AD, Orr SL, Defta DM, Taylor G, Bigler ED, Cohen DM, Mihalov LK, Bacevice A, Bangert BA, Ware AL. Posttraumatic headache and clinical recovery after pediatric concussion. Journal of the International Neuropsychological Society 2025. epub:1-13; DOI: 10.1017/S1355617725000128.
Orr SL, Kuziek J, Ali S, Anderson E, Birnie KA, Hershey AD, Khanna P, Kirton A, Sajobi T, Freedman SB. Remote electrical neuromodulation to treat children and adolescents with migraine in the emergency department: a randomized double-dummy pilot trial. Headache 2025; 65 (6):1015-1026; DOI: 10.1111/head.14838.
2024
Vives-Mestres M, Casanova A, Silberstein SD, Hershey AD, Orr SL. Clinical factors associated with day-to-day peak pain severity in individuals with chronic migraine: A cohort study using daily prospective diary data. Headache 2024; 64(8):995-1004.
Lindsay R, Kalifa A, Kuziek J, Kabbouche M, Hershey AD, Orr SL. The safety and efficacy of onabotulinumtoxinA injections for children and adolescents with chronic migraine: a systematic review and meta-analysis. Headache 2024; 64(10):1200-1216; DOI: https://doi.org/10.1111/head.14798.
Cho L, Bell TK, Craddock L, Godfrey K, Hershey AD; Kuziek J, Stokoe M, Millar K, Orr SL*, Harris AD*. Region-specific changes in brain glutamate and gamma-aminobutyric acid across the migraine attack in children and adolescents; Pain 2024; DOI: 10.1097/j.pain.0000000000003289.
Robblee J, Minen MT, Friedman BW, Cortel-LeBlanc MA, Cortel-LeBlanc A, Orr SL. 2023 protocol for update to acute treatment of adults with migraine in the emergency department: the American Headache Society evidence assessment of parenteral pharmacotherapies; Headache 2024; DOI: 10.1111/head.14744.
Martin E, Kuziek J, Rasiah J, Orr SL. Evaluating patient and family preferences for acute and preventive pediatric headache treatment. Headache 2024; 64(8):950-966.
Rizvi BA, Kuziek J, Cho LY, Ronksley PE, Noel MN, Orr SL. Anxiety and depressive symptoms and migraine-related outcomes in children and adolescents. Headache 2024;64(4):342-351.
Nania C, Noyek SE, Soltani S, Katz J, Fales J, Birnie KA, Orr SL, McMorris CA, Noel MN. Peer victimization, posttraumatic stress symptoms, and chronic pain: A longitudinal examination. J Pain 2024;DOI 10.1016/j.jpain.2024.104534.
Pavlova M, Noel M, Orr SL, Walker A, Madigan S, McDonald SW, Tough SC, & Birnie KA. Early childhood risk factors for later onset of pediatric chronic pain: A multi-method longitudinal study. BMC Pediatrics 2024;24(1):508.
Beveridge JK, Walker A, Orr SL, Wilson AC, Birnie KA, Noel M. Parent anxiety, depression, protective responses, and parenting stress in the context of parent and child chronic pain: A daily diary study of parent variability. Journal of Pain 2024; 25(8):104512.
Nilles C, Williams JV, Patten S, Pringsheim TM, Orr SL. Lifestyle factors associated with frequent recurrent headaches in children and adolescents. Neurology 2024;102(6):e209160.
Rizvi BA, Kuziek J, Cho LY, Ronksley PE, Noel MN, Orr SL. Anxiety and depressive symptoms and migraine-related outcomes in children and adolescents. Headache 2024;64(4):342-351.
Pavlova M, Ahola Kohut S, Jordan I, Sumpton J, Schraeder K, Orr SL, Craddock,L, Noel MN, Birnie KA. ACT-based intervention for parents living with chronic pain: Feasibility and acceptability study. Clinical Practice in Pediatric Psychology 2024;12(2):170-180.
2023
Beveridge JK, Noel M, Soltani S, Neville A, Orr SL, Madigan S, Birnie KA. The association between parent mental health and pediatric chronic pain: a systematic review and meta-analysis. Pain. 2023 Dec 6. DOI: 10.1097/j.pain.0000000000003125
Lipton RB, Pozo-Rosich P, Orr SL, Reed ML, Fanning KM, Dabruzzo B, Buse DC. Impact of monthly headache days on migraine-related quality of life: Results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) study. Headache 2023; DOI: https://doi.org/10.1111/head.14629
Nilles C, Williams JVA, Patten S, Pringsheim TM, Orr SL. Association between peer victimization, gender diversity, mental health, and recurrent headaches in adolescents: A Canadian population-based study. Neurology 2023; DOI: 10.1212/WNL.0000000000207738
Cortel-LeBlanc MA, Orr SL, Dunn M, James D, Cortel-LeBlanc A. Managing and preventing migraine in the emergency department: a review. Annals of Emergency Medicine 2023; DOI: https://doi.org/10.1016/j.annemergmed.2023.05.024
Sharpless LK, Kesselheim A., Orr SL, Darrow J. Variation in endpoints in FDA medication approvals: a review of acute and preventive migraine medications. Neurology 2023; DOI: https://doi.org/10.1212/WNL.0000000000207544
Zaslawski Z, Dib K, Tsang VWL, Orr SL, Birnie KA, Lowthian T, Alidina Z, Chesick-Gordis M, Kelly LE. Co-designing clinical trials alongside youth with chronic pain. Paediatric & Neonatal Pain 2023; epub:DOI 10.1002/pne2.12105
VanderPluym JH, Victorio MCC, Oakley CB, Rastogi RG, Orr SL. Beyond the guidelines: a narrative review of treatments on the horizon for migraine in children and adolescents. Neurology 2023; DOI: 10.1212/WNL.0000000000207677
Martin EG, Rasiah J, Claassen CS, Waywitka J, Merritt AM, Pringsheim TM, Shearer KA, Tsang VWL, Stevens KE, Sheehan-Klassen CE, Suddaby P, Orr SL. Engaging youth and parents in pediatric research. Paediatrics & Child Health 2023; epub: https://doi.org/10.1093/pch/pxac111
Van Lerssel JJ, Tang K, Beauchamp M, Bresee N, Cortel-LeBlanc A, Craig W, Doan Q, Gravel J, Lyons T, Mannix R, Orr SL, Zemek R, Yeates KO. Association of Posttraumatic Headache With Symptom Burden After Concussion in Children. JAMA Network Open 2023; 6(3): e231993
Marbil MG, Ware AL, Galarneau JM, Minish NM, Hershey AD, Orr SL, Defta DM, Taylor G, Bigler ED, Cohen DM, Mihalov LK, Bacevice A, Bangert BA, Yeates KO. Longitudinal trajectories of posttraumatic headache after pediatric mild traumatic brain injury. Cephalalgia 2023; 6(3): e231993
2022
Orr SL, Shapiro RE. The elephant in the room: how the underfunding of headache research stunts the field. Headache 2022; 62(9): 1234-1238.
Marshall A, Lindsay R, Clementi MA, Gelfand AA, Orr SL. Outpatient approach to resistant and refractory migraine in children and adolescents: a narrative review. Current Neurology and Neuroscience Reports 2022; 22(10): 611-624.
Falla K, Kuziek J, Mahnaz SR, Noel MN, Ronksley PE, Orr SL. Anxiety and depressive symptoms and disorders in children and adolescents with migraine: a systematic review and meta-analysis. JAMA Pediatrics 2022; 176(12): 1176-1187.
Myers KA, Barmherzig R, Raj NR, Berrahmoune S, Ingelmo P, Saint-Martin C, Khan AQ, Kouri M, Morris C, Hershey AD, Kacperski J, Kabbouche MA, Mohamed N, Rao RR, Lagman-Bartolome AM, Gelfand AA, Szperka CL, Orr SL. The spectrum of indomethacin-responsive headaches in children and adolescents. Cephalalgia 2022; 42(8): 793-797.
Hammond NG, Colman I, Orr SL. Adverse childhood experiences and incidence of migraine in Canadian adolescents: a prospective cohort study. Headache 2022; 62(3): 319-328.
2021
Vives-Mestres M, Casanova A, Hershey AD, Orr SL. Perceived stress and pain severity in individuals with chronic migraine: A longitudinal cohort study using daily prospective diary data. Headache 2021; 61(8): 1245-1254.
Pace A, Orr SL, Rosen NL, Safdieh JE, Cruz GB, Sprouse-Blum AS. The state of headache medicine education in North America: An observational, survey-based study of Neurology clerkship directors and Curriculum Deans. Headache 2021; 61(6): 854-862.
Christensen J, Beveridge JK, Wang M, Orr SL, Noel M, Mychasiuk R. A pilot study investigating the role of gender in the intergenerational relationships between gene expression, chronic pain, and adverse childhood experiences in a clinical sample of youth with chronic pain. Epigenomes 2021; 5(9): 1-17.
Vives-Mestres M, Casanova A, Buse D, Donoghue S, Houle TT, Lipton R, Mian A, Shulman KJ, Orr SL. Individual-level patterns of perceived stress throughout the migraine cycle: a longitudinal cohort study using daily prospective data. Headache 2021; 61(1): 90-102.
2020
Pavlova M, Orr SL, Noel M. Parent-child reminiscing about past pain as a preparatory technique in the context of children's pain: a narrative review and call for future research. Children 2020; 7(9): 130.
Orr SL, Gelfand AA, Hranilovich J, Irwin SL, Kabbouche M, Lagman-Bartolome AM, Lavell C, O'Brien HL, Rajapakse T, Rao R, Szperka C, Werner K, VanderPluym J, Yonker M, Hershey AD. The Development of the medical transfer packet for transition of care of the pediatric headache patient. Headache 2020; 60(10): 2589-2591.
Falla K, Ronksley P, Noel M, Orr SL. Internalizing symptoms in pediatric migraine: a systematic review protocol. Headache 2020; 60(4): 761-770.
Orr SL, Turner A, Kabbouche MA, Horn PS, O'Brien HL, Kacperski J, LeCates S, White S, Weberding J, Miller MN, Powers SW, Hershey AD. The profile and prognosis of youth with status migrainosus: results from an observational study. Headache 2020; 60(5): 878-888.
Hanes I, Orr S, Davila J, Kirton A, Sell E. Thrombolysis in a child with acute arterial ischemic stroke without large vessel occlusion. Can J Neurol Sci 2020; 47(2): 275-277.
Orr SL, OʼSullivan L, Zemek R, Ward NM, McMillan HJ. Family perspectives on visiting the pediatric emergency department for migraine: a qualitative study. Pediatr Emerg Care 2020; 36(6): e310-e317.
2019
Strasser LE, Orr SL, McMillan HJ, Callen DJA. Pediatric neurology workforce in Canada: a 5 year update. Canadian Journal of Neurological Sciences 2019; 00: 1-9.
Hammond NG, Orr SL, Colman I. Early life stress in adolescent migraine and the mediational influence of symptoms of depression and anxiety in a Canadian cohort. Headache 2019; 59(10): 1687-1699.
Orr SL, Turner A, Kabbouche MA, Horn PS, O'Brien HL, Kacperski J, LeCates S, White S, Weberding J, Miller MN, Powers SW, Hershey AD. Predictors of short-term prognosis while in pediatric headache care: an observational study. Headache 2019; 59(4): 543-555
2018
Orr SL, Kabbouche MA, O’Brien HL, Kacperski J, Powers SW, Hershey AD. Pediatric migraine: evidence-based management and future directions. Nature Reviews Neurology 2018; 14(9): 515-527
Orr SL. The evidence for the role of nutraceuticals in the management of pediatric migraine: a review. Current Pain and Headache Reports 2018; 22(5): 37
Szperka CL, VanderPluym J, Orr SL, Oakley CB, Qubty W, Patniyot I et al. Recommendations on the use of anti-CGRP monoclonal antibodies in children and adolescents. Headache 2018; 58(10): 1658-1669.
Orr SL, Richer L, Barrowman N, Zemek R. Oral dexamethasone for the prevention of acute migraine recurrence in pediatric patients presenting to the emergency department with migraine: a pilot randomized controlled trial. Cephalalgia Reports 2018; 1: 1-8.
Orr SL, Kabbouche MA, Horn PS, O’Brien HL, Kacperski J, LeCates S, White S, Weberding J, Miller MN, Powers SW, Hershey AD. Predictors of first-line treatment success in children and adolescents visiting an infusion center for acute migraine. Headache 2018; 58(8): 1194-1202.
2017
Orr SL, Christie SN, Akiki S, McMillan HJ. Disability, quality of life and pain coping in pediatric migraine: an observational study. J Child Neurol 2017; 32(8): 717-724.
Orr SL, Ramsay T, Christie SN, Dodick D, Gladstone J, Dowlatshahi D. The Non-inferiority margins in migraine research (NIMM) survey. Headache 2017; 57(5): 729-736.
Orr SL, Potter BK, Ma J, Colman I. Migraine and mental health in a population-based sample of adolescents. Can J Neurol Sci 2017; 44(1): 44-50.
2016
Orr SL. Diet and nutraceutical interventions for headache management: a review of the evidence. Cephalalgia 2016; 36(12): 1112-33.
Orr SL, Friedman BW, Christie SN, Minen M, Bamford C, Kelley N, Tepper D. Management of adults with acute migraine in the emergency department: The American Headache Society evidence assessment of parenteral pharmacotherapies. Headache 2016; 56(6): 911-940.
Doja A, Orr SL, McMillan HJ, Kirton A, Brna P, Esser M, Tang-Wai R, Major P, Poulin C, Prasad N, Selby K, Weiss SK, Yeh EA and Callen DJA. Canadian pediatric neurology workforce survey and consensus statement. Can J Neurol Sci 2016; 43(3): 402-409.
2015
Seeger TA, Orr SL, Bodell L, Rajapakse T, Lockyear L, Barlow KM. Occipital nerve blocks for pediatric post-traumatic headache: a case series. J Child Neurol 2015; 30(9): 1142-1146.
Orr SL, Becker W, Davenport J, Dilli E, Dodick D, Giammarco R, Gladstone J, Leroux E, Pim H, Dickinson G, Christie SN. Canadian Headache Society systematic review & recommendations on the treatment of migraine in emergency settings. Cephalalgia 2015; 35(3): 271-284.
2014
Orr SL, Venkateswaran S. Nutraceuticals in the prophylaxis of pediatric migraine: evidence-based review and recommendations. Cephalalgia 2014; 34(8): 568-583.
Orr SL, Dos Santos MP, Jurencak R, Michaud J, Miller E, Doja A. Central nervous system venulitis presenting as migraine. Headache 2014; 54(3): 541-544.