OnabotulinumtoxinA for youth with migraine

OnabotulinumtoxinA is an approved treatment for adults, but not for use in children and adolescents, with chronic migraine. Several studies, including two clinical trials, have looked at the use of OnabotulinumtoxinA injections in youth with migraine, but there is no recent summative work on this.

We are doing a systematic review on the safety and efficacy of OnabotulinumtoxinA injections in youth with migraine; we review all of the published studies on the topic, rate their quality, and pull key data from them, to provide a comprehensive overview of what the science says on the topic.

The results will provide a broad, unbiased, contextualized review on the available evidence for using OnabotulinumtoxinA injections in youth with migraine. This will help to guide practice patterns and where future studies will focus in this area.